Radioiodination and biological evaluation of candesartan as a tracer for cardiovascular disorder detection.
نویسندگان
چکیده
The goal of the study aims to evaluate newly radioiodinated candesartan (CAN) as a potential cardiovascular tracer. CAN was labeled using 125 I with chloramine-T (Ch-T) and N-bromosuccinimide (NBS) with full characterization of cold Iodo-candesartan. Factors such as pH, reaction temperature, reaction time, substrate, and oxidizing agent amounts were studied to optimize the radioiodination of CAN. The optimum radiochemical yield of 125 I-CAN was 98%. The labeled compound was separated and purified using high-pressure liquid chromatography. The biological distribution indicates the suitability of 125 I-CAN as a novel tracer to detect cardiovascular disorders.
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ورودعنوان ژورنال:
- Journal of labelled compounds & radiopharmaceuticals
دوره 59 12 شماره
صفحات -
تاریخ انتشار 2016